Cancer is one of the leading causes of death worldwide. Conventional cancer treatments have considerable side effects and may not always succeed in their intended response, taking a toll on patients and their families. CAR-T cell therapy is a novel form of cancer treatment using modified immune cells to target cancerous cells in the body with increased accuracy and precision. The goal of this project was to identify changes in gene expression between different groups of patients who responded differently to CAR-T cell therapy that can then be used to predict patient response to this treatment and thus, minimize its side effects. These findings are important because they may improve the viability of CAR-T cell therapy as an alternative to conventional cancer treatments.